Department of Chemical Biology and Genetics

Department of Chemical Biology and Genetics The main research directions of Department of Chemical Biology and Genetics include especially development of new chemical molecules specifically interacting with key proteins of cell signaling and regulatory pathways. We develop this field continuously and the result is number of biologically active natural substances and their derivatives, e.g. topolins, olomoucine, roscovitine, betulines, pyratine, chemopreventive substances etc.. 
First group of fractional tasks is focused on searching and development of substances targeted to key cell mechanisms – cell cycle and apoptosis. This research aim to development of biomolecules oriented to molecular targets that are decisive for rise of tumor cells. 
Second task group is devoted to targeted plant regulators modulating plant phytohormonal status. We perform especially synthesis of new substances using classical and combinatorial chemistry, isolation and characterization of natural substances with provable effects on enzyme inhibition, protein-deregulation, chemoprevention, growth-regulation and with generally biological effects. We also perform modification of chosen high-effective chemical individuals aiming to develop inhibitors/activators and (ant)agonists effective in nanomolar concentrations. Development of appropriate tests and their implementation into routine, mainly robotic screening of existing chemical libraries, natural substances, plants and microorganisms extracts and also newly prepared derivatives are part of this research direction as well. We perform biological activity testing of prepared compounds in plant biotests including their interaction with key enzymes of perception and phytohormones metabolism. Growth-regulatory properties of new substances will be tested also using „high-through put” phenotyping system in standard and stress conditions in future. Field tests on economically important crops will be done as well.

    Karel DOLEŽAL
    Head of Department, Senior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 940, karel.dolezal@upol.cz
    Jitka FRÉBORTOVÁ
    Senior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 871, jitka.frebortova@upol.cz
    Lucie PLÍHALOVÁ (SZÜČOVÁ)
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 940, lucie.szucova@upol.cz
    Ondřej NOVÁK
    Head of the department, Laboratory of Growth Regulators, Institute of Experimental Botany
    +420 585 634 853, ondrej.novak@upol.cz
    Lukáš SPÍCHAL
    Senior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 855, lukas.spichal@upol.cz
    Radoslav KOPRNA
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 945, radoslav.koprna@upol.cz
    Jiří GRÚZ
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 632 173, jiri.gruz@upol.cz
    Tomáš GUCKÝ
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 784, tomas.gucky@upol.cz
    Marek ZATLOUKAL
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 953, marek.zatloukal@upol.cz
    Lucie RÁROVÁ
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 854, lucie.rarova@upol.cz
    Aleš PĚNČÍK
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 862, ales.pencik@upol.cz
    Markéta GEMROTOVÁ
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 899, marketa.gemrotova@upol.cz
    Tibor BÉRES
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 860, tibor.beres@upol.cz
    Václav MIK
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 785, vaclav.mik@upol.cz
    Tomáš POSPÍŠIL
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 786, t.pospisil@upol.cz
    Nuria De DIEGO
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 830, nuria.de@upol.cz
    Jan HUMPLÍK
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 945, jan.humplik@upol.cz
    Jana KLÁSKOVÁ
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 899, jana.klaskova@upol.cz
    Lenka PLAČKOVÁ
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 861, lenka.plackova@upol.cz
    Lucia GALLOVÁ
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 899, lucia.gallova@upol.cz
    Václav BAZGIER
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 769, vaclav.bazgier@upol.cz
    Hana KOZUBÍKOVÁ
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 783, hana.kozubikova@upol.cz
    Veronika ŠUBERTOVÁ
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 914, veronika.subertova@upol.cz
    Ondřej BÍBA
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 632 173, ondrej.biba@upol.cz
    Jan ŠIMURA
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 862, jan.simura@upol.cz
    Hana VYLÍČILOVÁ (MALEČKOVÁ)
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 783, hana.vylicilova@upol.cz
    Kristýna FLOKOVÁ
    Ph.D. student, Faculty of Science, Palacký University Olomouc
    +420 585 634 862, kristyna.flokova@upol.cz
    Jaroslav NISLER
    Researcher, Laboratory of growth regulators, Institute of Experimental Botany
    +420 585 634 784, jaroslav.nisler@upol.cz
    Jana ŠIROKÁ
    Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 899, jana.siroka@upol.cz
    Petra AMAKOROVÁ
    Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 858, petra.amakorova@upol.cz
    Michaela ŠUBRTOVÁ
    Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 632 173, michaela.subrtova@upol.cz
    Miloslava ŠUBOVÁ
    Biology technician, Faculty of Science, Palacký University Olomouc
    +420 585 634 830, miloslava.subova@upol.cz
    Veronika TUREČKOVÁ
    Specialist, Faculty of Science, Palacký University Olomouc
    +420 585 634 862, veronika.tureckova@upol.cz
    Jarmila BALONOVÁ
    Laboratory worker, Faculty of Science, Palacký University Olomouc
    +420 585 634 830, jarmila.balonova@upol.cz
    Tereza KUBICOVÁ
    Secretary, Faculty of Science, Palacký University Olomouc
    +420 585 634 670, +420 585 634 941, tereza.kubicova@upol.cz
    Dominika HÁJKOVÁ
    Ph.D. Student, Faculty of Science, Palacký University Olomouc
    +420 585 634 856, dominika.hajkova@upol.cz
    Jan LAZECKÝ
    Ph.D. Student, Faculty of Science, Palacký University Olomouc
    +420 585 634 945, jan.lazecky@upol.cz
    Asta ŽUKAUSKAITE, Dr.
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 670, astazukauskaite@gmail.com
    Eva ŘEZNÍČKOVÁ
    Researcher, Laboratory of growth regulators, Institute of Experimental Botany
    +420 585 634 914, eva.reznickova@upol.cz
    Radek JORDA, Ph.D.
    Junior Researcher, Faculty of Science, Palacký University Olomouc
    +420 585 634 854, radek.jorda@upol.cz
    Veronika MALÍNKOVÁ
    Ph.D. Student, Faculty of Science, Palacký University Olomouc
    +420 585 634 783, veronika.malinkova@upol.cz
    Jana OKLEŠŤKOVÁ, Ph.D.
    Scientific worker, Faculty of Science, Palacký University in Olomouc
    +420 585 634 853, jana.oklestkova@upol.cz
    Jaromír MIKULÍK, Ph.D.
    Scientific worker, Faculty of Science, Palacký University in Olomouc
    +420 585 634 862, jaromir.mikulik@upol.cz