Scientists from the Regional Centre of Advanced Technologies and Materials (RCPTM), the Centre of the Region Haná for Biotechnological and Agricultural Research, and the UP Faculty of Medicine have discovered a unique mechanism that enables bacteria to defend themselves against silver nanoparticles, which are widely used in antibacterial therapy. This mechanism does not require the bacteria to undergo genetic changes, and differs significantly from mechanisms of antibiotic resistance. The scientists have also found a way to suppress bacterial resistance to nanosilver, which could be crucial in addressing the global antibiotics crisis. The revolutionary discovery was published in January on the cover page of the journal Nature Nanotechnology, arguably the world’s most prestigious journal in the nanotechnology field. This is also the first paper written exclusively by Czech authors that has been published in this journal.